Hydrochloric Acid → HCID 178434707, compound

Participants

Reaction Steps

A solution of HCl in ethanol (5M, 43 ml) was added to a stirred, cooled solution of [2S,3S]-1-[(5-(dimethylaminomethyl)-1H-[1,2,3]triazol-4-yl)methyl]-2-phenyl-3-[3-(5-methyltetrazol-1 -yl)-5-(trifluoromethyl)phenylmethoxy]piperidine (49 mg, 90 mmol) in ethanol (2 ml). The solvent was evaporated under reduced pressure and the residue was triturated with ether (5 ml). The solid was collected and dried in vacuo to give [2S, 3S]-1-[(5-(dimethylaminomethyl)-1H-[1,2,3]triazol-4-yl)methyl]-2-phenyl-3-[3-(5-methyltetrazol-1-yl)-5-(trifluoromethyl)phenylmethoxy]piperidine dihydrochloride as a tan-coloured solid (55 mg), mp 134°-137° C., 1H (D2O) δ 7.78 (3H, m), 7.44-7.00 (7H, m), 4.87 (1H, d, J=13.5 Hz), 4.47 (1H, d, J=13.5 Hz), 4.40 (1H, d, J=15.3 Hz), 4.36 (1H, d, J=15.3 Hz), 4.30 (1H, s), 3.83-3.61 (5H, m), 3.29 (1H, d, J=14.6 Hz), 2.67 (6H, s), 2.51 (3H, s), 2.31 (2H, m), 1.85 (1H, m), and 1.71 (1H, m).

Provenance & Evidence