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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 355412Generated: October 29, 2026

3',5'-Difluoro-2',4'-dibenzyloxyacetophenone → 3',5'-Difluoro-2',4'-dihydroxyacetophenone

https://huagongshe.com/reaction/355412

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3',5'-Difluoro-2',4'-dibenzyloxyacetophenoneHCID 18942328—
SolventEthyl AcetateHCID 8857—
Product3',5'-Difluoro-2',4'-dihydroxyacetophenoneHCID 18942333—

Reaction Steps

A 0.4M solution of Compound 25 over 10% Pd/C (10% wt. to Compound 25) in EtOAc is hydrogenated at 40 psi for 24 hours. The reaction is filtered and concentrated in vacuo followed by sublimation to yield Compound 26.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05830912
Source datasetuspto-grants-1998_11
ORD IDord-9c0e9924124d4a3d8c6d1bad28f8e4dd
Source noteuspto-grants-1998_11