Dichloromethane → HCID 11482338, compound

Participants

Reaction Steps

With ice-cooling, m-chloroperbenzoic acid (1.66 g, 9.6 mmol) was added to a mixture of 3-hydroxymethyl-10-methylphenothiazine (1.94 g, 8.0 mmol) and dichloromethane (30 ml), and the mixture was stirred for 1.5 hours and then at room temperature for 1.5 hours. A saturated sodium bicarbonate aqueous solution was added to the reaction mixture and the reaction product was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and then concentrated under a reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent; methanol:chloroform=3:97 then 10:90) to give the title compound (1.95 g, 7.52 mmol, 94%) as colorless crystals.

Provenance & Evidence