反应详情

To a cooled solution of 3-aminobutyric acid (13 g) in 2M NaOH (130 ml) is added benzoyl chloride (19.7 g) over the course of two hours. The mixture is allowed to warm to room temperature. Washing with diethyl ether, acidifying of the aqueous phase with 20% HCI, extraction with diethyl ether, drying over MgSO4, evaporation of the solvent and recrystallization in ether/hexane gives the title compound m.p. 150°-152° C. (compound 1.16, Table 1).

1. washWashing with diethyl ether, acidifying of the aqueous phase with 20% HCI, extraction with diethyl ether
2. dry with materialdrying over MgSO4, evaporation of the solvent and recrystallization in ether/hexane