Hydrochloric Acid → HCID 9930514, compound

Participants

Reaction Steps

N-(Diphenyl phosphinyl)-N-(2-phenylethyl)glycine methyl ester (160 mg, 0.41 mmol) is dissolved in methanol (2.5 mL). To this is added hydroxylamine hydrochloride (57 mg, 0.81 mmol), followed by a 2 mmol of a 25% methanolic solution of sodium methoxide. The reaction is stirred for 16 hours, neutralized with 1N hydrochloric acid and concentrated. The crude product is purified by silica gel flash chromatography to give 41.6 mg (26%) of N-hydroxy-2-[[diphenylphosphinyl](2-phenylethyl)-amino]-acetamide as a colorless solid: MS-IS m/z 395 [M+H]+, 417 [M+Na]+, 433 [M+K]+. (R1 =phenyl ethyl, R2 =H, R3 =phenyl, R4 =phenyl).

Provenance & Evidence