Methanol → HCID 9543420, compound

Participants

Reaction Steps

N-Benzyloxy-2(R)-[[(S)-methylphenylphosphinyl]benzylamino]-4-methylpentanamide (334 mg, 0.719 mmol) and 80 mg 10% Pd/C were evacuated in a flask. To this is added 10 mL methanol and a hydrogen atmosphere is introduced. The reaction is allowed to stir at room temperature for 2 hours at which time the reaction appears complete by TLC. The mixture is filtered through celite; the filtrate is collected and evaporated to give a white glassy solid. The product is dissolved in ethyl acetate and hexane is added dropwise until the product begins to precipitate to give N-hydroxy-2(R)-[[(R)-methylphenylphosphinyl]benzylamino]-4-methylpentanamide as colorless solid: MS-IS: m/z 375 [M+H]+, 397 [M+Na]+, 413 [M+K]+.

Provenance & Evidence