HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 4-Acetyl-4-phenylpiperidine hydrochloride | HCID 2723767 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide | HCID 22741756 | 196.7% |
Reaction Steps
8 g of bromine are added rapidly at RT to a suspension of 11.98 g of 4-acetyl-4-phenylpiperidine hydrochloride in 200 ml of DCM, and the reaction mixture is left stirring overnight at RT. It is diluted by adding 200 ml of ether, and the precipitate formed is drained and washed with ether. 17.88 g of the expected product are obtained after drying under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05830906 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-7e9dc4906751498b9c07a52496974797 |
| Source note | uspto-grants-1998_11 |