HCID 131720916, compound → HCID 131720915, compound

Participants

Reaction Steps

0.67 g of 1,6-bis-O-(4'-methoxycarbonyl-biphenyl-4-yl)-2,5-O-methylene-D-mannitol was heated under reflux for 16 hours in 15 ml of concentrated sodium hydroxide solution and 15 ml of methanol; thereupon the mixture was evaporated and the residue was acidified with dilute hydrochloric acid. The precipitate of 1,6-bis-O-(4'-carboxy-biphenyl-4-yl)-2,5-O-methylene-D-mannitol which thereby formed was filtered off, dissolved in 5 ml of acetic anhydride and 5 ml of pyridine and stirred at room temperature for 16 hours. Now, the mixture was again evaporated, the residue was poured into dilute hydrochloric acid and the mixture was filtered; there was thus obtained 3,4-di-O-acetyl-1,6-bis-O-(4'-carboxy-biphenyl-4-yl)-2,5-O-methylene-D-mannitol in the form of colorless crystals, MS: m/z 669.4 ([M-H]-).

Provenance & Evidence