反应详情

1.40 g of dimethyl (S)-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-isophthalate were stirred at room temperature for 16 hours with 4 ml of sodium hydroxide solution (28%) in 50 ml of methanol. After neutralization with 6N hydrochloric acid, the methanol was distilled off in a water-jet vacuum. The residue was poured on to ice-water, extracted with methylene chloride, the combined methylene chloride phases were washed with water, dried over magnesium sulfate, filtered and evaporated. There was obtained (S)-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-isophthalic acid, MS: m/z 296 ([M]+).

1. distillationAfter neutralization with 6N hydrochloric acid, the methanol was distilled off in a water-jet vacuum
2. additionThe residue was poured on to ice-water
3. extractionextracted with methylene chloride
4. washthe combined methylene chloride phases were washed with water
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customevaporated