HCID 18666645, compound → HCID 18661325, compound

Participants

Reaction Steps

3.5-Di-O-benzoyl-2-deoxy-2-fluoro-α,β-D-arabinofuranosyl azide [compound (7)] (see Example 2 of PCT International Laid-Open publication WO 93/10137 specification of PCT/JP 92/01489 application) in the form of a colorless syrup (350 mg) was dissolved in dioxane (7 ml). Into this solution, hydrogen was blown at room temperature in the presence as catalyst of palladium black for 1 hour to conduct the catalytic reduction intended, thereby convert the azido group of compound (7) into amino group. The reaction solution obtained was filtered and the filtrate was concentrated up to about a half volume thereof, and then diluted with dichloroethane (50 ml). The diluted solution was dried over calcium chloride, and then a small amount of triethylamine was added thereto, followed by concentration to afford the titled compound (8) as a colorless syrup (324 mg). Crude yield: 99%.

Provenance & Evidence