HCID 57061525, compound → HCID 54469757, compound

HRID 355504Notes

Reaction equation

HRID 355504 reaction equation
[C:1]([O:9][C@@H:10]1[C@@H:14]([CH2:15][O:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:13][C@@H:12]([N:25]2[C:29]([N:30]3[C:34](=[O:35])[C:33]4=[CH:36][CH:37]=[CH:38][CH:39]=[C:32]4[C:31]3=[O:40])=[C:28]([C:41]([O:43]C(C)(C)C)=[O:42])[N:27]=[CH:26]2)[C@H:11]1[F:48])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O.ClCCl>[C:1]([O:9][C@@H:10]1[C@@H:14]([CH2:15][O:16][C:17](=[O:24])[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[O:13][C@@H:12]([N:25]2[C:29]([N:30]3[C:31](=[O:40])[C:32]4=[CH:39][CH:38]=[CH:37][CH:36]=[C:33]4[C:34]3=[O:35])=[C:28]([C:41]([OH:43])=[O:42])[N:27]=[CH:26]2)[C@H:11]1[F:48])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 57061525HCID 57061525, compound2×

Product 1

HCID 54469757HCID 54469757, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Compound (11) obtained in step (2) above (2.00 g) was dissolved in a mixture (30 ml) of trifluoroacetic acid-dichloromethane (1:4) and the resulting solution was kept overnight at room temperature, when the deesterification of compound (11) occurred. The reaction solution was concentrated and the solid obtained was washed with diethyl ether to yield the titled compound (12) (1.77 g) which was insoluble in diethyl ether. Yield: 97%.

Workup

  1. concentrationThe reaction solution was concentrated
  2. customthe solid obtained
  3. washwas washed with diethyl ether

Sources & evidence

ORD record
ord-5dce783b4bc642b0b91e1a7f7e4d246b
Source dataset
uspto-grants-1998_11
Patent number
US05831072

Reaction notes

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