Ether hydrochloride → HCID 54097139, compound

HRID 355505Notes

Reaction equation

HRID 355505 reaction equation
[C:1]([O:9][C@@H:10]1[C@@H:14]([CH2:15][O:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:13][C@@H:12]([N:25]2[C:29]([N:30]3[C:34](=[O:35])[C:33]4=[CH:36][CH:37]=[CH:38][CH:39]=[C:32]4[C:31]3=[O:40])=[C:28]([C:41](=[O:45])[CH:42]=[N+]=[N-])[N:27]=[CH:26]2)[C@H:11]1[F:46])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:47].C(OCC)C>ClCCl>[C:1]([O:9][C@@H:10]1[C@@H:14]([CH2:15][O:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:13][C@@H:12]([N:25]2[C:29]([N:30]3[C:34](=[O:35])[C:33]4=[CH:36][CH:37]=[CH:38][CH:39]=[C:32]4[C:31]3=[O:40])=[C:28]([C:41](=[O:45])[CH2:42][Cl:47])[N:27]=[CH:26]2)[C@H:11]1[F:46])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 54238193HCID 54238193, compound

Product 1

HCID 54097139HCID 54097139, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The solid containing compound (14) obtained in step (5) above was dissolved in dichloromethane (5 ml), to which was then added a 1M hydrogen chloride-diethyl ether solution (0.5 ml), and the resultant mixture was allowed to react for 0.5 hours to produce the titled compound (15). The reaction solution so obtained was diluted with dichloromethane and washed with water, and the organic layer obtained was dried over anhydrous sodium sulfate and then concentrated to yield the titled compound (15) as a solid (190 mg). Yield from compound (12): 90%.

Workup

  1. customto react for 0.5 hours

Sources & evidence

ORD record
ord-795e3e8b57a943e4a4505717b1aea159
Source dataset
uspto-grants-1998_11
Patent number
US05831072

Reaction notes

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