Sodium methanolate methanol → HCID 178516779, compound

HRID 355509Notes

Reaction equation

HRID 355509 reaction equation
C([O:9][C@@H:10]1[C@@H:14]([CH2:15][O:16]C(=O)C2C=CC=CC=2)[O:13][C@@H:12]([N:25]2[C:29]3[N:30]=[CH:31][NH:32][CH2:33][C:34](=[O:35])[C:28]=3[N:27]=[CH:26]2)[C@H:11]1[F:36])(=O)C1C=CC=CC=1.C[O-].[Na+].CO>CO>[F:36][C@H:11]1[C@H:10]([OH:9])[C@@H:14]([CH2:15][OH:16])[O:13][C@H:12]1[N:25]1[C:29]2[N:30]=[CH:31][NH:32][CH2:33][C:34](=[O:35])[C:28]=2[N:27]=[CH:26]1

Participants

4

Reactant 2

HCID 23694274Sodium methanolate methanolHCID 178525573HCID 178525573, compound2×

Product 1

HCID 178516779HCID 178516779, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension in methanol (4 ml) of compound (19) (100.5 mg) as obtained in step (10) above was added a 0.5M sodium methylate-methanol solution (0.6 ml). The resultant mixture was stirred at room temperature for 1 hour to conduct the intended reaction. Thus, the debenzoylation of compound (19) occurred to produce the titled compound (20).

Workup

  1. customthe intended reaction

Sources & evidence

ORD record
ord-7a302e0b00954750907c7f6173327e4a
Source dataset
uspto-grants-1998_11
Patent number
US05831072

Reaction notes

Loading…