HCID 57307244, compound → HCID 53998996, compound

HRID 355511Notes

Reaction equation

HRID 355511 reaction equation
[C:1]([O:4][C@@H:5]1[C@@H:9]([CH2:10][O:11][C:12](=[O:14])[CH3:13])[O:8][C@@H:7]([N:15]2[C:19]([N:20]3[C:24](=[O:25])[C:23]4=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]4[C:21]3=[O:30])=[C:18]([C:31]([O:33]C(C)(C)C)=[O:32])[N:17]=[CH:16]2)[C@@H:6]1[Cl:38])(=[O:3])[CH3:2]>FC(F)(F)C(O)=O.ClCCl>[C:1]([O:4][C@@H:5]1[C@@H:9]([CH2:10][O:11][C:12](=[O:14])[CH3:13])[O:8][C@@H:7]([N:15]2[C:19]([N:20]3[C:21](=[O:30])[C:22]4=[CH:29][CH:28]=[CH:27][CH:26]=[C:23]4[C:24]3=[O:25])=[C:18]([C:31]([OH:33])=[O:32])[N:17]=[CH:16]2)[C@@H:6]1[Cl:38])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 57307244HCID 57307244, compound2×

Product 1

HCID 53998996HCID 53998996, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Compound (34) obtained in step (2) above (1.50 g) was dissolved in a mixture of trifluoroacetic acid-dichloromethane (1:4) (25 ml), and the solution so obtained was allowed to stand at room temperature overnight so that there occurred de-esterification of compound (34). The resulting reaction solution was concentrated to leave a solid. This solid was then washed with diethyl ether to yield the titled compound (35) (1.31 g) which was insoluble in diethyl ether (1.31 g). Yield: 97%.

Workup

  1. customthe solution so obtained
  2. customThe resulting reaction solution
  3. concentrationwas concentrated
  4. customto leave a solid
  5. washThis solid was then washed with diethyl ether

Sources & evidence

ORD record
ord-8b9951a8e9664ce98f054160fb01c0b6
Source dataset
uspto-grants-1998_11
Patent number
US05831072

Reaction notes

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