Piperidine → HCID 178511795, compound

Participants

Reaction Steps

Fmoc-D-His-Tyr(OBn)-CONH(CH2)2Ph (0.6 g, 0.8 mmol) in CH2 Cl2 (5 mL) was treated with piperdine (0.14 g, 1.6 mmol). The resulting mixture was stirred 2 hours before concentrating in vacuo and purifying the resulting by flash chromatography (SiO2, CHCl3 :MeOH eluent) to give D-His-Tyr(OBn)-CONH(CH2)2Ph. The foam was dissolved in CH2C2 (5 mL) and treated with 4-phenoxyphenyl isocyanate (0.05 g, 0.23 mmol). The resulting mixture was stirred 1 hour at room temperature, concentrated in vacuo, and purified the resulting oil by flash chromatography (SiO2, CHCl3 :MeOH eluent) to obtain (4-PhOPh)NHCO-D-His-Tyr(OBn)-CONH(CH2)2Ph as a foam; ES-MS 723 (m+1).

Provenance & Evidence