HCID 57207766, compound → HCID 54408787, compound

Participants

Reaction Steps

A solution of 4(N-tert-butoxycarbonyl-L-valyl)amino-2,2-difluoro-3-hydroxy-5[4(2-{N-MORPHOLINYL}ETHYLOXY)PHENYL]N-benzyl pentanamide (0.19 g, 0.28 mmol) in formic acid (15 ml) was stirred at room temperature for 4 hours. After evaporation of the solvent in vacuo, the residue was diluted with ethyl acetate (50 ml) and washed three times with a saturated solution of sodium carbonate (3×10 ml) and brine (10 ml). The organic layer was dried over magnesium sulphate.

Provenance & Evidence