HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-(trifluoromethyl)benzene → N,N-Dibutyl-3-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| Reactant | Dibutylamine | HCID 8148 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N,N-Dibutyl-3-(trifluoromethyl)aniline | HCID 18943007 | — |
| Product | N,N-Dibutyl-4-(trifluoromethyl)aniline | HCID 18943008 | — |
Reaction Steps
2.0 mmol of 4-chlorobenzotrifluoride, 2.4 mmol of di-n-butylamine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium (II) in 10 ml of toluene are reacted according to the GWI to give 4-trifluoromethylphenyl-di-n-butylamine and 3-trifluoromethylphenyl-di-n-butylamine in the ratio 7:1 in 58% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05831128 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-78047edeb39c43e8a9f0ce6ab17d7f15 |
| Source note | uspto-grants-1998_11 |