HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 1-(4-Fluorophenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Benzene, 1-chloro-4-fluoro- | HCID 9604 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(4-Fluorophenyl)piperidine | HCID 10866927 | — |
| Product | HCID 10921100 | HCID 10921100 | — |
Reaction Steps
2.0 mmol of 4-chlorofluorobenzene, 2.4 mmol of piperidine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium(II) in 10 ml of toluene are reacted according to the GWI to give 4-fluorophenylpiperidine and 3-fluorophenylpiperidine in the ratio 2:1 in 75% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05831128 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-29dd7c87eeb74214955228b88959e0bd |
| Source note | uspto-grants-1998_11 |