Acetone → 4-(4,4-Dimethyl 3-(2-methoxyethyl) 5-oxo 2-thioxo 1-imidazolidinyl) 2-(trifluoromethyl) benzonitrile

HRID 355592Notes

Reaction equation

[CH3:1][C:2]1([CH3:25])[C:6](=N)[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=2)[C:4](=[S:20])[N:3]1[CH2:21][CH2:22][O:23][CH3:24].C(Cl)Cl.CC(C)=[O:31]>>[CH3:1][C:2]1([CH3:25])[C:6](=[O:31])[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:18])([F:17])[F:19])[CH:9]=2)[C:4](=[S:20])[N:3]1[CH2:21][CH2:22][O:23][CH3:24]

Participants

Reactant 3

HCID 180Acetone

HCID 6344Dichloromethane

HCID 22116964HCID 22116964, compound

Product 1

HCID 221169494-(4,4-Dimethyl 3-(2-methoxyethyl) 5-oxo 2-thioxo 1-imidazolidinyl) 2-(trifluoromethyl) benzonitrile

Procedure

Using the procedure of Example 71, the product of Example 78 was reacted to obtain the expected product melting at 98°-99° C. with a Rf=0.32 (eluant: methylene chloride--acetone (99-1))

Sources & evidence

ORD record: ord-d622aabd2241420e9ffab3e4e31752b3
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE035956

Reaction notes

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