HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86753304, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-Methyl-2-butanone | HCID 11251 | — |
| Reactant | 2-(1-Methylhydrazinyl)-5-(trifluoromethyl)pyridine | HCID 2777782 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 86753304 | HCID 86753304 | — |
Reaction Steps
A solution of 1-[5-trifluoromethylpyrid-2-yl]-1-methyl hydrazine (5.9 g; 0.031 mol), 3-methyl-2-butanone (5.6 g; 0.065 mol) and p-toluenesulphonic acid (0.1 g) in xylene (30 ml) was heated under reflux, with water removal (azeotrope), for 7 h. The solution was concentrated to yield an oil which was purified by distillation (70° C./72 mbar) to yield 3-methyl-2-butanone 1-[5-trifluoromethylpyrid-2-yl]-1-methyl hydrazone as a yellow oil (5.8 g; 72%). ##STR15##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05833885 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-e68a99cb397e46adadd6a7ae09f6b5e2 |
| Source note | uspto-grants-1998_11 |