Methylhydrazine → HCID 18940147, compound

Participants

Reaction Steps

2-Chloro-4,6-bis(trifluoromethyl)pyridine (19.4 g; 0.078 mol) was treated with several portions of methyl hydrazine (4.2 g; 0.090 mol) and stirred under nitrogen at room temperature for 24 h. The oil/solid mixture was treated with 5M aqueous NaOH to basify (pHil) and extracted with ethyl acetate. The organic extracts were dried and evaporated to afford 1-[4,6-bis[trifluoromethyl]pyrid-2-yl]-1-methyl hydrazine as an oil (18.4 g; 91%). ##STR25##

Provenance & Evidence