反应详情

温度

20 °C

5.68 pbw of 2-amino-9-(4-methylphenyl)acridine (compound 12d) were dissolved with 20.3 pbw of methanesulfonyl chloride and 22.4 pbw of diazabicyclo[2.2.2]octane in 120 pbv of acetonitrile and the solution heated for 2 hours under reflux. After cooling to 20° C., filtration was carried out and the red filtrate added dropwise to 1000 pbv of 0.5% strength ammonia solution. After standing overnight, the precipitate was filtered off by suction and crystallized from 135 pbv of ethanol. Yield: 1.76 pbw (20% of theory), light yellow needles. Mp.: 217°-219° C.

1. temperaturethe solution heated for 2 hours
2. temperatureunder reflux
3. filtrationfiltration
4. additionthe red filtrate added dropwise to 1000 pbv of 0.5% strength ammonia solution
5. filtrationthe precipitate was filtered off by suction
6. customcrystallized from 135 pbv of ethanol