反应详情

Methyl-4,4-dimethyl-3-oxovalerate (15.8 g, 0.1 mol) and 2-methoxy-5-nitroaniline (16.8 g, 0.01 mol) were taken up in toluene (150 mL) in a round bottomed flask fitted with a Dean-Stark trap. The mixture was heated to a vigorous reflux while the MeOH side-product was distilled off and removed. After 4 hours, the mixture was cooled and the toluene removed in vacuo. The residue was recrystallized from acetonitrile to yield 27 g of the desired condensation product.

1. customfitted with a Dean-Stark trap
2. temperatureThe mixture was heated to
3. distillationwas distilled off
4. customremoved
5. temperaturethe mixture was cooled
6. customthe toluene removed in vacuo
7. customThe residue was recrystallized from acetonitrile
8. customto yield 27 g of the desired
9. customcondensation product