Sodium Hydroxide → HCID 15895950, compound

HRID 355729Notes

Reaction equation

HRID 355729 reaction equation
[CH3:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[C:8]2[C:3]=1[N:4]=[CH:5][CH:6]=[N:7]2.[OH-].[Na+]>C(O)C>[NH2:12][C:11]1[C:2]([CH3:1])=[C:3]2[C:8](=[CH:9][CH:10]=1)[N:7]=[CH:6][CH:5]=[N:4]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15895949HCID 15895949, compound

Product 1

HCID 15895950HCID 15895950, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5-methyl-6-nitroquinoxaline (1.4 g), ethanol (100 mL) and stannous chloride dihydrate (7.2 g) is heated at reflux for three hours, cooled to below room temperature in an ice bath and treated with 1.0 N NaOH solution (120 mL). The mixture is then extracted with chloroform (2×1000 mL). The combined extracts are dried over potassium carbonate, filtered, and rotary evaporated to give 6-amino-5-methylquinoxaline.

Workup

  1. temperatureis heated
  2. temperatureat reflux for three hours
  3. temperaturecooled to below room temperature in an ice bath
  4. extractionThe mixture is then extracted with chloroform (2×1000 mL)
  5. dry with materialThe combined extracts are dried over potassium carbonate
  6. filtrationfiltered
  7. customrotary evaporated

Sources & evidence

ORD record
ord-acefebb97fb24e04a2f868b2bec08cc7
Source dataset
uspto-grants-1998_11
Patent number
US05834470

Reaction notes

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