Water → Ethyl 4-(1H-1,2,4-triazol-1-yl)benzoate

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	1H-1,2,4-Triazole	HCID 9257	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	Benzoic acid, 4-fluoro-, ethyl ester	HCID 67976	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Product	Ethyl 4-(1H-1,2,4-triazol-1-yl)benzoate	HCID 22628005	73.2%

Reaction Conditions

Temperature	90 °C

Reaction Steps

1,2,4-Triazole (0.82 g, 0.01 mol), ethyl 4-fluorobenzoate (2 g, 0.01 mol) and anhydrous potassium carbonate (1.43 g, 0.01 mol) was dissolved in DMSO (30 ml) and heated to 90° C. for 18 h. The solution was poured into water (50 ml), extracted with ethyl acetate (50 ml), dried (sodium sulphate), filtered and evaporated to dryness under reduced pressure. The white solid was purified by flash column chromatography (silica, diethyl ether) to afford a white solid (1.59 g, 73%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05834471
Source dataset	uspto-grants-1998_11
ORD ID	ord-044a82c45c654a089ad860363c8e8202
Source note	uspto-grants-1998_11