2-[N-Ethyl-N-(2-(phenethyl)benzyl)amino]pyridine-5-carboxylic acid → 2-[N-(5-bromo-2-(phenethyl)benzyl)-N-ethylamino]-5-pyridine carboxylic acid
Reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:6]([CH:21]=1)[CH2:7][N:8]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([O:19]C)=[O:18])=[CH:13][N:12]=1)[CH2:9][CH3:10].C(N(C1C=CC(C(O)=O)=CN=1)CC1C=CC=CC=1CCC1C=CC=CC=1)C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:22][CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[C:6]([CH:21]=1)[CH2:7][N:8]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([OH:19])=[O:18])=[CH:13][N:12]=1)[CH2:9][CH3:10]Participants
3
Procedure
2-[N-(5-bromo-2-(phenethyl)benzyl)-N-ethylamino]-5-pyridine carboxylic acid was prepared from methyl 2-[N-(5-bromo-2-(phenethyl) benzyl)-N-ethylamino]-5-pyridinecarboxylate using a similar method to that described in Example 4 paragraph (A).
Sources & evidence
- ORD record
- ord-40b89eb4f6e44369ba6b063c04984d8a
- Source dataset
- uspto-grants-1998_11
- Patent number
- US05834468
Reaction notes
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