1-Bromo-3-chloropropane → HCID 18940733, compound

Participants

Reaction Steps

To a solution of 3-(5-methyl-1,2,4-oxadiazol-3-yl)-β-carboline (0.25 g, 0.001 mol) in anhydrous DMF (30 mL) was added 50% sodium hydride in mineral oil (0.03 g, 0.0011 mol). The mixture was stirred for 1 h at room temperature, and then carefully added to a solution of 1-bromo-3-chloropropane (0.17 g, 0.0011 mol) in anhydrous DMF (20 mL). The resulting mixture was stirred at ambient temperature for 96 h. The reaction mixture was concentrated in vacuo, and the crude product was purified twice on a silica gel column 1) (Eluent: CH2Cl2 /methanol (9:1)); 2) (Eluent: ethyl acetate/toluene (1:1)) to give the title compound 0.21 g (64%). M.p. 130°-135° C.

Provenance & Evidence