2,8-Diacetylamino-1-tetralone → 2-Acetylaminomethyl-8-amino-5-chloro-1-tetralone

HRID 355958Notes

Reaction equation

HRID 355958 reaction equation
C([NH:4][C:5]1[CH:6]=[CH:7][C:8]([Cl:18])=[C:9]2[C:14]=1[C:13](=[O:15])[CH:12]([C:16]#[N:17])[CH2:11][CH2:10]2)(=O)C.[C:19](NC1CCC2C(=C(NC(=O)C)C=CC=2)C1=O)(=[O:21])[CH3:20]>>[C:19]([NH:17][CH2:16][CH:12]1[CH2:11][CH2:10][C:9]2[C:14](=[C:5]([NH2:4])[CH:6]=[CH:7][C:8]=2[Cl:18])[C:13]1=[O:15])(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 120472982,8-Diacetylamino-1-tetraloneHCID 224494878-Acetylamino-5-chloro-2-cyano-1-tetralone

Product 1

HCID 224495222-Acetylaminomethyl-8-amino-5-chloro-1-tetralone

Procedure

The procedure of Example 1-(4) was followed by using 1.20 gm of the compound prepared in (3) above, instead of 2,8-diacetylamino-1-tetralone. The reaction product was post-treated to obtain 1.20 gm of the title compound.

Workup

  1. additionThe reaction product was post-treated

Sources & evidence

ORD record
ord-c764122670b84f79b070096c983c1dbf
Source dataset
uspto-grants-1998_11
Patent number
US05834476

Reaction notes

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