HCID 22449427, compound → HCID 22449547, compound

HRID 355966Notes

Reaction equation

HRID 355966 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:3]=1[CH:4]([N:16]1[C:24](=[O:25])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:17]1=[O:26])[CH2:5][CH2:6][C:7]2=[O:15].FC1C=CC([N+]([O-])=O)=C2C=1C(N1C(=O)C3C(=CC=CC=3)C1=O)CCC2=O>>[NH2:12][C:9]1[CH:10]=[CH:11][C:2]([CH3:1])=[C:3]2[C:8]=1[C:7](=[O:15])[CH2:6][CH2:5][CH:4]2[N:16]1[C:24](=[O:25])[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]1=[O:26]

Participants

3

Reactant 2

HCID 22449427HCID 22449427, compoundHCID 22449542HCID 22449542, compound

Product 1

HCID 22449547HCID 22449547, compound

Procedure

The reaction was carried out in the same manner as in Example 13-(10), except that 145 mg of the compound prepared in (2) above was used instead of 5-fluoro-8-nitro-4-(1,3-dioxoisoindoline-2-yl)-1-tetralone of Example 13-(10). The reaction product was post-treated to produce 75 mg of the title compound.

Workup

  1. additionThe reaction product was post-treated

Sources & evidence

ORD record
ord-c31edee9b64841febde907f055b7d6a1
Source dataset
uspto-grants-1998_11
Patent number
US05834476

Reaction notes

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