3-(Chloromethyl)pyridine → HCID 12205864, compound

HRID 355983Notes

Reaction equation

HRID 355983 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]([Mg]Br)=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 183583-(Chloromethyl)pyridineHCID 178419612HCID 178419612, compound

Product 1

HCID 12205864HCID 12205864, compound

Procedure

The above mentioned compound was prepared similarly to the procedure described in Arch. Pharm. 308, 209 (1975) from 5-benzyloxy-indolyl-magnesium bromide and 3-chloromethyl-pyridine. After recrystallization from acetonitrile, the desired compound was obtained.

Workup

  1. customwas prepared similarly to the procedure
  2. customAfter recrystallization from acetonitrile

Sources & evidence

ORD record
ord-6751233022f340d48220df3199580779
Source dataset
uspto-grants-1998_11
Patent number
US05834493

Reaction notes

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