反应详情

A mixture of 3-pyridin-propionaldehyde (1 g; 0.0074 mol) and of 4-bromophenylhydrazin hydrochloride (1.8 g; 0.0074 mol) with acetic acid (4.44 ml) in absolute ethanol (50 ml) was refluxed for 3 hours. The reaction was then quenched with a saturated solution of aqueous sodium carbonate and the product was extracted with ethyl acetate. The organic extract was dried (MGSO4) and evaporated under vacuum. After purification by Flash Chromatography on silica gel using as eluent methylene chloride/methanol (98/2), the desired compound was obtained.

1. customThe reaction was then quenched with a saturated solution of aqueous sodium carbonate
2. extractionthe product was extracted with ethyl acetate
3. extractionThe organic extract
4. customwas dried (MGSO4)
5. customevaporated under vacuum
6. customAfter purification by Flash Chromatography on silica gel using as eluent methylene chloride/methanol (98/2)