Sodium borohydride → HCID 18940871, compound

HRID 355987Notes

Reaction equation

HRID 355987 reaction equation
[BH4-].[Na+].[Br-].[CH3:4][O:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[C:9]2[CH2:15][C:16]1[CH:17]=[N+:18]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:19]=[CH:20][CH:21]=1>CO>[CH3:4][O:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[C:9]2[CH2:15][C:16]1[CH2:17][N:18]([CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:19][CH2:20][CH:21]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18940826HCID 18940826, compound

Product 1

HCID 18940871HCID 18940871, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium borohydride in pellets (1.5 g; 0.0396 mol) was added to a cold (0° C.) stirring mixture of 3[(5-methoxy-1H-indol-3-yl)methyl]-1-benzyl-pyridinium bromide (5.8 g; 0,0141 mol) in methanol (130 ml). The reaction mixture was stirred at 0° C. for 2 hours. The product precipitated as a whitepink solid was filtered and washed with cold methanol and dried under vacuum.

Workup

  1. stirringThe reaction mixture was stirred at 0° C. for 2 hours
  2. customThe product precipitated as a whitepink solid
  3. filtrationwas filtered
  4. washwashed with cold methanol
  5. customdried under vacuum

Sources & evidence

ORD record
ord-f56c7ca498834952918ab8986ad00fd5
Source dataset
uspto-grants-1998_11
Patent number
US05834493

Reaction notes

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