Ethyl chloroformate → HCID 18940855, compound

HRID 355988Notes

Reaction equation

HRID 355988 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH2:18][C:19]1[CH2:20][N:21](CC2C=CC=CC=2)[CH2:22][CH2:23][CH:24]=1>C1(C)C=CC=CC=1>[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH2:18][C:19]1[CH2:20][N:21]([C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH2:22][CH2:23][CH:24]=1

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 18940871HCID 18940871, compound

Product 1

HCID 18940855HCID 18940855, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
75 °C

Procedure

Ethyl chloroformate (5.74 ml; 0.060 mol) was added to a mixture of 5-methoxy-3-(N-benzyl-1,2,5,6-tetrahydro-pyridin-3-ylmethyl)-1H-indole (4 g; 0.012 mol) in toluene (430 ml). The reaction mixture was heated at 75° C. for 3 hours. The reaction mixture was then cooled and the desired compound was obtained after evaporation of the solvent. The compound was used as such without further purifiction.

Workup

  1. temperatureThe reaction mixture was then cooled

Sources & evidence

ORD record
ord-4a38a875750b4312a961f2873e0755e8
Source dataset
uspto-grants-1998_11
Patent number
US05834493

Reaction notes

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