Sodium Hydroxide → HCID 3510845, compound

HRID 355998Notes

Reaction equation

HRID 355998 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.Br.[Br:12][CH2:13][CH2:14][NH2:15].[OH-].[Na+]>>[Br:12][CH2:13][CH2:14][NH:15][C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][CH:4]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 678794-Fluorobenzoyl chlorideHCID 27742172-Bromoethylamine hydrobromide

Product 1

HCID 3510845HCID 3510845, compoundYield 68.9%

Procedure

4-fluoro-benzoyl chloride (3 ml; 0.026 mol) was added dropwise to a cold (~0° C.). Stirring mixture of 2-bromo-ethyl-amine hydrobromide (5 g; 0.0236 mol) and 10% aqueous sodium hydroxide (21 ml; 0.052 mol). Crystalline product started to precipitate out of the reaction mixture almost immediately. After 15 minutes of stirring, the product was collected by filtration, triturated with diethyl ether and dried under vacuum giving the desired compound as a white solid (4 g).

Workup

  1. customto precipitate out of the reaction mixture almost immediately
  2. stirringAfter 15 minutes of stirring
  3. filtrationthe product was collected by filtration
  4. customtriturated with diethyl ether
  5. customdried under vacuum

Sources & evidence

ORD record
ord-e89358ac693c46e9a61a37e31c812a67
Source dataset
uspto-grants-1998_11
Patent number
US05834493

Reaction notes

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