HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 356015Generated: October 29, 2026
Sodium Hydroxide → 6-Chloro-5-methyl-2,3-dihydro-1H-indole
https://huagongshe.com/reaction/356015
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 6-chloro-5-methyl-1H-indole | HCID 10773354 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Chloro-5-methyl-2,3-dihydro-1H-indole | HCID 22186080 | 95% |
Reaction Steps
6-Chloro-5-methylindole (D9) (0.109 g, 0.66 mmol) was stirred at 15° C. in glacial acetic acid (3 ml), and sodium cyanoborohydride (0.125 g, 1.98 mmol) was added. The mixture was stirred at 15° C. for 2 h, diluted with water (40 ml), basified with solid NaOH, and extracted with ether. The extract was dried (Na2SO4) and evaporated to give the title compound (0.105 g, 95%) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05834494 |
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| Source dataset | uspto-grants-1998_11 |
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| ORD ID | ord-98567b1f3638426da8000ac349344795 |
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| Source note | uspto-grants-1998_11 |
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