HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-phenyl-2,3-dihydro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 5-phenyl-1H-indole | HCID 11458210 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-phenyl-2,3-dihydro-1H-indole | HCID 13497475 | 93.1% |
Reaction Steps
5-Phenylindole (D29) (0.85 g, 4.4 mmoles) was dissolved in glacial acetic acid (20 ml) and treated with sodium cyanoborohydride (1.34 g, 22 mmoles) at ambient temperature for 2 hrs. Water (100 ml) was added and the mixture basified with sodium hydroxide. Extraction with dichloromethane gave the title compound (D30) (0.8 g, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05834494 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-30430f06a5fc48ba9d15099162d111a8 |
| Source note | uspto-grants-1998_11 |