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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 356024Generated: October 31, 2026

5-Chloroindole → 5-Chloroindoline

https://huagongshe.com/reaction/356024

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-ChloroindoleHCID 87110—
ReactantSodium cyanoborohydrideHCID 5003444—
SolventAcetic AcidHCID 176—
Product5-ChloroindolineHCID 11759694%

Reaction Steps

5-Chloroindole was reduced in the usual way with sodium cyanoborohydride in glacial acetic acid to give the title compound (D35) (0.96 g, 94%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05834494
Source datasetuspto-grants-1998_11
ORD IDord-dbe665242223416e94a661fd248120a2
Source noteuspto-grants-1998_11