5-Bromoindole → 5-(Thiophen-3-yl)-1H-indole

HRID 356027Notes

Reaction equation

HRID 356027 reaction equation

Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[S:11]1[CH:15]=[CH:14][C:13](B(O)O)=[CH:12]1>>[S:11]1[CH:15]=[CH:14][C:13]([C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[CH:5]3)=[CH:12]1

Participants

3

Reactant 2

HCID 249055-Bromoindole

HCID 581760Thiophene-3-boronic acid

Product 1

HCID 149732275-(Thiophen-3-yl)-1H-indole

Procedure

The title compound was prepared as in (D29) from 5-bromoindole and thiophene-3-boronic acid to give (D40) (1.1 g, 100%).

Workup

customto give (D40) (1.1 g, 100%)

Sources & evidence

ORD record: ord-ba417346bf6e4daf94f286c3bb3ecfbd
Source dataset: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05834494

Reaction notes

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