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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 356028Generated: October 30, 2026

Sodium cyanoborohydride → 5-(3-Thienyl)indoline

https://huagongshe.com/reaction/356028

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium cyanoborohydrideHCID 5003444—
Reactant5-(Thiophen-3-yl)-1H-indoleHCID 14973227—
SolventAcetic AcidHCID 176—
Product5-(3-Thienyl)indolineHCID 20099954100%

Reaction Steps

5-(3-Thienyl)indole D40 was reduced in the usual way with sodium cyano borohydride in glacial acetic acid to give the title compound (D41) (1.0 g, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05834494
Source datasetuspto-grants-1998_11
ORD IDord-897ff97657e549949f21d17da38e6886
Source noteuspto-grants-1998_11