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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 356029Generated: October 26, 2026

5-(trifluoromethyl)-1H-indole → 5-(trifluoromethyl)-2,3-dihydro-1H-indole

https://huagongshe.com/reaction/356029

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(trifluoromethyl)-1H-indoleHCID 2763075—
ReactantSodium cyanoborohydrideHCID 5003444—
SolventAcetic AcidHCID 176—
Product5-(trifluoromethyl)-2,3-dihydro-1H-indoleHCID 1544778983%

Reaction Steps

5-Trifluoromethylindole (D42) was reduced in the usual way with sodium cyanoborohydride in glacial acetic acid to give the title compound (D43) (0.18 g, 83%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05834494
Source datasetuspto-grants-1998_11
ORD IDord-deee3ed489584b6381f46b6427a12cf6
Source noteuspto-grants-1998_11