Sodium Hydroxide → HCID 18940906, compound

Participants

Reaction Steps

1-Acetylchloro-5-vinylindoline (D61) (0.13 g), and 10% aqueous NaOH (5 ml) were heated at reflux in ethanol (20 ml) for 2.5 hours, cooled and treated with an excess of saturated aqueous NH4Cl. The mixture was partitioned between ethyl acetate and brine. The organic extracts were dried (Na2SO4) and evaporated to dryness under reduced pressure affording the title compound as a brown oil (0.13 g) which was used without further purification.

Provenance & Evidence