反应详情

5-(N,N-dimethylamino)indoline (D13) (0.29 g, 1.79 mmol) was added to solution of 3-pyridylisocyanate derived from nicotinoyl azide (0.52 g, 1.2 eq) heated at reflux in dry toluene for 1.5 h. The solution was allowed to stand overnight evaporated under reduced pressure and purified by column chromatography (SiO2, CHCl3 /MeOH 2-5%) to afford a pale blue oil which on trituration with Et2O afforded a pale blue solid (550 mg, 99%).

1. temperatureheated
2. customevaporated under reduced pressure
3. custompurified by column chromatography (SiO2, CHCl3 /MeOH 2-5%)
4. customto afford a pale blue oil which on trituration with Et2O