HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Nitro-1-(3-pyridylcarbamoyl)indoline Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | 3-Pyridinecarbonyl Azide | HCID 19914 | — |
| Reactant | 5-Nitroindoline | HCID 36219 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-Nitro-1-(3-pyridylcarbamoyl)indoline Hydrochloride | HCID 18940945 | 76% |
Reaction Steps
This material was prepared from nicotinoyl azide (0.43 g, 2.9 mmol) and 5-nitroindoline (0.38 g, 2.3 mmol), and conversion of the precipitated urea to the salt using excess HCl in ether, following the procedure of Example 2. This gave the title compound (0.64 g, 76%) as a light yellow powder, m.p. 244°-7° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05834494 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-aafc92b2637a4682a1f40d81e42fab24 |
| Source note | uspto-grants-1998_11 |