3-Isocyanatopyridine → 6-Chloro-5-methylthio-1-(3-pyridylcarbamoyl)indoline

HRID 356057Notes

Reaction equation

HRID 356057 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[S:11][CH3:12].[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N:19]=[C:20]=[O:21])[CH:14]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:20](=[O:21])[NH:19][C:15]2[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=2)=[CH:4][C:3]=1[S:11][CH3:12]

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 105599346-Chloro-5-methylthioindoline

Product 1

HCID 106871306-Chloro-5-methylthio-1-(3-pyridylcarbamoyl)indolineYield 81%

Procedure

6-Chloro-5-methylthioindoline (D48) (0.70 g, 3.51 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The crude product was recrystallised from ethanol/diethyl ether to give the title compound (0.91 g, 81%) as a white crystalline solid m.p. 241°-242° C.

Workup

  1. customThe crude product was recrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-3c738efee9224e08a9d50ad72d592fbf
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

Loading…