3-Isocyanatopyridine → 6-Chloro-5-propyl-1-(3-pyridylcarbamoyl)indoline

HRID 356061Notes

Reaction equation

HRID 356061 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[CH2:11][CH2:12][CH3:13].[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([N:20]=[C:21]=[O:22])[CH:15]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:21](=[O:22])[NH:20][C:16]2[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=2)=[CH:4][C:3]=1[CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 189409236-Chloro-5-propylindoline

Product 1

HCID 107816556-Chloro-5-propyl-1-(3-pyridylcarbamoyl)indoline

Procedure

6-Chloro-5-propylindoline (D54) (57 mg, 0.3 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The crude product was recrystallised from ethanol/diethyl ether to give the title compound as a white crystalline solid m.p. =218°-220° C.

Workup

  1. customThe crude product was recrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-bdd41116e3ce465e886021a08354e8fd
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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