3-Isocyanatopyridine → HCID 10495578, compound

HRID 356064Notes

Reaction equation

HRID 356064 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[CH:11]([CH3:13])[CH3:12].[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([N:20]=[C:21]=[O:22])[CH:15]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:21](=[O:22])[NH:20][C:16]2[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=2)=[CH:4][C:3]=1[CH:11]([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 18940944HCID 18940944, compound

Product 1

HCID 10495578HCID 10495578, compoundYield 57%

Procedure

6-Chloro-5-isopropylindoline (D58) (0.4 g, 2.05 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The product was recrystallised from ethanol/diethyl ether to give the title compound (0.36 g, 57%) as a white crystalline solid m.p.=183°-185° C.

Workup

  1. customThe product was recrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-368d6fa8d5344a219bf2a55642c64a8b
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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