3-Isocyanatopyridine → HCID 18940908, compound

HRID 356068Notes

Reaction equation

HRID 356068 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[S:11][CH2:12][CH2:13][CH3:14].[N:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N:21]=[C:22]=[O:23])[CH:16]=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:22](=[O:23])[NH:21][C:17]2[CH:16]=[N:15][CH:20]=[CH:19][CH:18]=2)=[CH:4][C:3]=1[S:11][CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 18940929HCID 18940929, compound

Product 1

HCID 18940908HCID 18940908, compoundYield 65%

Procedure

6-Bromo-5-propylthioindoline (D83) (0.095 g, 0.35 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The product was recrystallised from ethanol/diethyl ether to give the title compound (0.089 g, 65%) as a white crystalline solid m.p. 224°-226° C.

Workup

  1. customThe product was recrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-8761eb957c644c4d87669f60334aa1f8
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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