3-Isocyanatopyridine → HCID 10384138, compound

HRID 356070Notes

Reaction equation

HRID 356070 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[S:11][CH3:12].[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N:19]=[C:20]=[O:21])[CH:14]=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:20](=[O:21])[NH:19][C:15]2[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=2)=[CH:4][C:3]=1[S:11][CH3:12]

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 10562221HCID 10562221, compound

Product 1

HCID 10384138HCID 10384138, compoundYield 71%

Procedure

6-Bromo-5-methylthioindoline (D85) (0.26 g, 1.06 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The product was recrystallised from ethanol to afford the title compound (0.27 g, 71%) as a white crystalline solid m.p. 242°-244° C.

Workup

  1. customThe product was recrystallised from ethanol

Sources & evidence

ORD record
ord-4d163b0fcbec4075ad85fcd66d9c92a7
Source dataset
uspto-grants-1998_11
Patent number
US05834494

Reaction notes

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