12-Oxa-2,6,10-triazatetradecanoic acid, 6-[(1,1-dimethylethoxy)carbonyl]-13,13-dimethyl-11-oxo-2-[2-(2-pyridinyl)ethyl]-10-propyl-, 1,1-dimethylethyl ester → HCID 18940747, compound

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Reaction Steps

A mixture of 2.084 g (3.6 mmol) of 1-propyl-9-[2-(2-pyridyl)-ethyl]-1,5,9-tri-BOC-1,5,9-triazanonane, 20 ml of methanol and 0.2 g of pre-hydrogenated rhodium oxide/platinum oxide (Nishimura catalyst) is hydrogenated at room temperature and under normal pressure until the absorption of hydrogen has ceased. After filtration and washing the catalyst with methanol, the filtrate is concentrated by evaporation in vacuo, yielding the title compound in the form of a colorless resin, Rf value=0.51 (silica gel/tert-butyl methyl ether).

Provenance & Evidence