Bromine → HCID 18940979, compound

HRID 356102Notes

Reaction equation

HRID 356102 reaction equation
[O:1]=[C:2]1[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1.[Br:11]Br>C(OCC)C>[Br:11][CH:3]1[CH2:4][CH2:5][C:6]2[CH:7]=[CH:8][O:9][C:10]=2[C:2]1=[O:1]

Participants

4

Reactant 2

HCID 24408BromineHCID 113209597(4H)-Benzofuranone, 5,6-dihydro-

Product 1

HCID 18940979HCID 18940979, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In 100 ml of diethyl ether, 1.09 g of 7-oxo-4,5,6,7-tetrahydrobenzofuran was dissolved, and 0.41 ml of bromine was added. The mixture was stirred at room temperature for one hour. The solvent was then evaporated, and the residue was subjected to silica gel column chromatography, whereby 1.13 g of 6-bromo-7-oxo-4,5,6,7-tetrahydrobenzofuran was obtained as the oil form from the fraction eluted with hexane-ethyl acetate (10:1).

Workup

  1. customThe solvent was then evaporated

Sources & evidence

ORD record
ord-555e8a6ff7ed4f719f7c6b5b11c6f3ab
Source dataset
uspto-grants-1998_11
Patent number
US05834499

Reaction notes

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